In 2008, he appeared in two movies about Jacques Mesrine, who was France's "public enemy number one" in the seventies.
Cassel received the 2009 Cesar award for best actor for his performance in Mesrine directed by Jean-Francois Richet.
In 2009, he made his debut as a singer on Zap Mama's album Re Creation, singing alongside them on the singles "Paroles, Paroles" and "Non, Non, Non".
Cassel's breakthrough role was in Mathieu Kassovitz's critically acclaimed film La Haine where he played a troubled youth from the deprived outskirts of Paris.He has gone on to act in a variety of films such as the moody L'Appartement (with Monica Bellucci before they married), the violent Dobermann, the genre-bending Le Pacte des Loups (in English, Brotherhood of the Wolf), and the highly controversial Irréversible, where he appears fully nude (with Monica Bellucci after they married).; born Vincent Crochon, 23 November 1966) is a French actor best known to English-speaking audiences through his film performances in Ocean's Twelve and Ocean's Thirteen, as well as Black Swan.Cassel is also renowned for playing the infamous French bank-robber Jacques Mesrine in Mesrine: Killer Instinct and Mesrine: Public Enemy Number One.The new fragrance, La Nuit de l'Homme, was launched worldwide in March 2009.
French film historian Tim Palmer describes Cassel as one of the most charismatic and idiosyncratic of all France's contemporary stars, working in both popular and more intellectual modes of cinema, typically playing characters that veer unpredictably between positive/alluring and negative/grotesque—often, in fact, within a single role and performance.An early appearance on British television was as Nicole's boyfriend in the 1994 Renault Clio advert which was used in the UK.In October 2008, Cassel was signed to be the face of a new Yves Saint Laurent men's fragrance.He will play Zumi in Rupert Sanders's samurai adventure fantasy film The Lost Sea Horizon, opposite Sandra Bullock and Fan Bingbing.Cassel has also appeared in a number of English-language films, such as Ocean's Twelve and Ocean's Thirteen, Derailed, Birthday Girl, The Messenger: The Story of Joan of Arc, Elizabeth, Eastern Promises, and Shrek (as the voice of Monsieur Hood), and in the Portuguese-language, Brazilian film Adrift (À Deriva).In 2006, he appeared in Sheitan, in which he played a shepherd who carries out satanic rituals.